Use and and Lose It dives into the revolutionary world of weight loss pharmaceuticals, focusing on the science behind these drugs, their market dynamics, and their profound impact on the weight loss industry. Through expert interviews and following the transformative journey of individuals beginning their treatment with Ozempic and Wegovy, the documentary explores how these medications have become game-changers, offering hope to millions while also sparking debate over their ethical implications, cost, and long-term efficacy.

The film delves into the business strategies of pharmaceutical giants like Novo Nordisk, highlighting the economic implications and competitive landscape shaped by these drugs. It also addresses the critical perspectives of healthcare professionals and public health advocates, raising questions about the sustainability of pharmaceutical-driven weight loss and the importance of comprehensive lifestyle changes.